In this paper, an advanced duplex scheme called cross-division duplex (XDD) is proposed to enhance uplink (UL) coverage in time division duplex (TDD) carriers by utilizing self-interference cancellation (SIC) capability at a base station. With XDD, it is possible to combine TDD’s ability to efficiently handle asymmetric UL and downlink (DL) traffic with frequency division duplex’s coverage advantage. To do so, XDD simultaneously operates UL and DL on the same TDD carrier but on different frequency resources. Such operation leads to severe interference on the received UL signal at the base station which requires two levels of SIC implementation; antenna and digital SIC. More than 50 dB of interference is removed through the antenna SIC using electromagnetic barriers between the transmitting and receiving antennas. The remaining interference is removed by the digital SIC based on estimating the non-linear channel of the circuit at the receiver baseband. It is verified by simulation and analysis that with the proposed XDD, the UL coverage can be improved by up to 2.37 times that of TDD. To check the feasibility of XDD, a Proof-of-Concept was developed where it was observed that the benefits of XDD can indeed be realized using the proposed SIC techniques.